Gabriele Ludewig, PhD

Assistant Professor
Dept. of Occupational and Environmental Health
The University of Iowa College of Public Health
100 Oakdale Campus, #234 IREH
Iowa City, IA 52242-5000
Phone: (319) 335-4650
Fax: (319) 335-4225
E-mail: gabriele-ludewig@uiowa.edu
Education
BS Department of Biology, University of Mainz, Germany 1977
MS Institute of Anthropology & Human Genetics, University of Mainz 1982
PhD Institute of Toxicology, University of Mainz 1991
PostDoc Department of Biology, The University of Kentucky 1992-1994


Courses Taught
The natural, biological, and medical sciences in environmental systems
Chemical carcinogenesis
Advanced toxicology

Brief Summary of Research Interests
Dr. Ludewig's research interests reflect her broad work experience. Special emphasis is directed towards three areas:
  • investigation of the mechanisms of cyto- and genotoxicity of xenobiotics and their metabolites, such as benzene metabolites, quinones of polycyclic aromatic hydrocarbons and PCBs, and the evaluation of these for their possible involvement in cancer induction
  • employment of modern molecular biology and yeast genetics methods to develop anti-microbial compounds and vaccines and to understand their mechanisms of action
  • analysis of the intra- and intercellular effects of anti-angiogenic compounds to explore their potential for cancer therapy

Selected Publications and Presentations

Tampal N.M., Robertson L.W., Srinivasan C., Ludewig G. (2003). Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1.Toxicol Appl Pharmacol. 187(3), 168-77. abstract

Srinivasan A., L.W. Robertson and G. Ludewig. (2002). Sulfhydryl binding and topoisomerase inhibition by PCB Metabolites.(2002)  Chem. Res. Toxicol. 15, 497-505. abstract

Srinivasan A. , H.-J. Lehmler, L. W. Robertson and G. Ludewig. (2001). Production of DNA strand breaks in vitro and Reactive Oxygen Species in vitro and in HL-60 cells by PCB Metabolites. Toxicological Sciences 60, 92-102 .  abstract

Xu Y., A. Krishnan, X.S. Wan, H. Majima, C. - C. Yeh, G. Ludewig, E. J. Kasarskis, and D. K. St. Clair (1999).   Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer.  Oncogene 18, 93 - 102. abstract

Espandiari P., G. Ludewig, H.P. Glauert, and L.W. Robertson (1998).  Activation of hepatic NF-kB by the herbicide Dicamba (2-methoxy-3, 6-dichlorobenzoic acid) in female and male rats.  J. Biochem. Molec. Toxicol. 12, 339-344. abstract

Ludewig G., A. Srinivasan, P. Espandiari, L.W. Robertson (1998).  Generation of reactive oxygen species (ROS) and genotoxicity by metabolies of polychlorinated biphenyls (PCBs).  Organohalogen Compounds 37, p. 143 - 146.

Ludewig G., A. Gagliardi, R.K. Munn, D.C. Collins (1997). Effects of somatostatin analogues and tamoxifen on angiogenesis in vivo and endothelial cells in vitro. 88th Annual Meeting of the American Association for Cancer Research, San Diego, CA (USA), Abstract # 1380

Ludewig G., G.G. Oakley, P. Espandiari, ande L.W. Robertson (1996). Production of superoxide and DNA strand breaks by diol metabolites of lower chlorinated biphenyls (PCBs). 87th Annual Meeting of the American Assoc. Cancer Res., Washington, DC (USA), Abstract #989

Ludewig G., Y. Li, and C. Staben (1995). Role of drug accumulation and efflux transporters in fungal pentamidine susceptibility. 18th Fungal Genetics Conference, Pacific Grove, CA, in: Fungal Genetics Newsletters

Amaro A.R., U. Bauer, G. Ludewig, and L.W. Robertson (1995). Chlorinated dihydroxybiphenyls and quinones: synthesis, reactivity, and cytotoxicity studies. The Toxicologist; 15, p. 50.

Ludewig G. and C. Staben (1994). Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae; Antimicrob. Agents Chemother. 38, 2850-2856. abstract

Ludewig G. and C. Staben (1994). Sensitivity of taxonomically diverse fungi to pentamidine isethionate, J. Eukaryot. Microbiol. 41, 103S.

Ludewig G., Y. Li, J.M. Williams and C. Staben (1994). Effects of Pentamidine Isethionate on Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 38, 1123-1128. abstract

Ludewig G., S. Dogra, F. Setiabudi, A. Seidel, F. Oesch and H.R. Glatt (1991). Quinones derived from polycyclic aromatic hydrocarbons: induction of diverse mutagenic and genotoxic effects in mammalian cells. in: Polynuclear Aromatic Hydrocarbons, M.Cooke, K.Loening, and J. Merrit (Eds.), Bartelle Press, 545-556.

Ludewig G., S. Dogra and H.R. Glatt (1989): Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells. Environmental Health Perspectives 82, 223-228. abstract

Glatt H.R., R. Padykdula, G.A. Berchtold, G. Ludewig, K.L. Platt, J. Klein and F. Oesch (1989). Multiple activation pathways of benzene leading to products with varying genotoxic characteristics. Environm. Health Perspect. 82, 81-89. abstract

Ludewig G. and H.R. Glatt (1988). Suppression of the appearance of 3-methylcholanthrene induced foci in C3H 10T1/2 cells by continuous post-treatment with dimethylsulfoxide, but not by acetone and ethanole. Naunyn-Schmiedeberg's Archives of Pharmacology, Suppl. to Vol. 337, R33.

Oesch F., B. Janik-Schmitt, G. Ludewig, H.R. Glatt, R. Wieser (1987). Glutaraldehyde-fixed transformed and non-transformed cells induce contact-dependent inhibition of growth in non-transformed C3H/10T1/2 mouse fibroblasts, but not in 3-methylcholanthrene-transformed cells.Eur. J. Cell Biol. 43(3), 403-407. abstract

Ludewig G. and H.R. Glatt (1986). Mutations in bacteria and sister chromatid exchanges in cultured mammalian cells are induced by different metabolites of benzene. Naunyn-Schmiedeberg's Archives of Pharmacology, Supplement to Vol. 332,. R21.

Glatt H.R., G. Ludewig, K.L. Platt, F. Waechter, I. Yona, S. Ben-Shoshan, P. Jerushalmy, J. Blum, F.Oesch (1985): Arene Imines, a new class of exceptionelly potent mutagens in bacterial and mammalian cells. Cancer Res. 45, 2600-2607.

 

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