Dr. Larry W. Robertson
Professor of Toxicology
The University of Iowa, College of Public Health


Recent Publications (1998-2006)

Izabela Kania-Korwel, A. Wayne Garrison, Jimmy K. Avants, Keri C. Hornbuckle, Larry W. Robertson, Wieslaw W. Sulkowski, and Hans-Joachim Lehmler, Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat. Environmental Science & Technology, In Press.

Ludewig, Gabriele; Harald Esch and Larry W. Robertson, Polyhalogenierte Bi- und Terphenyle. Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim. Review, In Press.

Luthe G., P.E.G. Leonards, G.S. Reijerink, H. Liu, J.E. Johansen, L.W. Robertson, Monofluorinated analogues of polybrominated diphenyl ethers (F-PBDEs) as analytical standards: Synthesis, NMR and GC-MS characterization and molecular orbital studies. Environ. Sci. Technol. 40, 3023-29 (2006).

Kunz S., H.-J. Schmitz, A. Buchmann, M. Schwarz, B. Schilling, O. Päpke, H.-J. Lehmler, L.W. Robertson and D. Schrenk. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicology Letters 164, 133–43 (2006). abstract

Ptak A., G. Ludewig, L.W. Robertson, H.-J. Lehmler and E.L. Gregoraszczuk. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicology Letters 164, 113–22 (2006). abstract

Wang L.-Q., H.-J. Lehmler, L.W. Robertson, and M.O. James. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem.-Biol. Interactions 159, 235-246 (2006). abstract

Kodavanti P.R.S., T.R. Ward, G. Ludewig, L.W. Robertson, and L.S. Birnbaum. Polybrominated Diphenyl Ether (PBDE) Effects in Rat Neuronal Cultures: 14C-PBDE Accumulation, Biological Effects, and Structure-Activity Relationships. Toxicological Sciences 88, 181–192 (2005). abstract

Kania-Korwel I., K.C. Hornbuckle, A. Peck, G. Ludewig, L.W. Robertson, W.W. Sulkowski, P. Espandiari, C.G. Gairola, H.-J. Lehmler. Congener specific tissue distribution of Aroclor 1254 and a highly chlorinated environmental PCB mixture in rats. Environmental Science & Technology 39, 3513-3520 (2005). abstract

Wang L.-Q., H.-J. Lehmler, L.W. Robertson, C.N. Falany and M.O. James. In vitro Inhibition of Human Hepatic and cDNA-expressed Sulfotransferase Activity with 3-Hydroxybenzo[a]pyrene by Polychlorobiphenylols. Environmental Health Perspectives 113, 680-687 (2005). free full-text article

Lehmler H.-J., L.W. Robertson, A.W. Garrison, P.R.S. Kodavanti, Effects of PCB 84 enantiomers on [3H] phorbol ester binding in rat cerebellar granule cells and 45Ca2+-uptake in rat cerebellum. Toxicology Lett. 156, 391-400 (2005). abstract

Ptak A., G. Ludewig, H.-J. Lehmler, A.K. Wójtowicz, L.W. Robertson and E.L. Gregoraszczuk. Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture. Reproductive Toxicology 20, 57-64 (2005). abstract

Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E, Robertson LW. Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in Low-Density Lipoprotein Receptor. Environ. Health Perspect. 113, 83-87 (2005). free full-text article

Kania-Korwel, Izabela, Sean Parkin, Larry W. Robertson and Hans-Joachim Lehmler. 2,4,5-Trichlorobiphenyl. Acta Crystallographica Section E, E60, o1652-o1653 (2004).

Ritchie, Justine M., Scott L. Vial, Laurence J. Fuortes, Larry W. Robertson, Haijun Guo, Victoria E. Reedy, Elaine M. Smith. Comparison of Proposed Frameworks for Grouping Polychlorinated Biphenyl Congener Data Applied to a Case-Control Pilot Study of Prostate Cancer. Environmental Research, 98(1), 104-13, (2004). abstract

Espandiari, P., Larry W. Robertson, Cidambi Srinivasan and Howard P. Glauert. Comparison of different initiation protocols in the resistant hepatocyte model. Toxicology 206(3), 373-8, (2005). abstract

Glauert, Howard P., Zijing Lu, Amita Kumar, R. Petruta Bunaciu, Sandip Patel, Job C. Tharappel, Divinia N. Stemm, Hans-Joachim Lehmler, Eun Y. Lee, Larry W. Robertson and Brett T. Spear. Dietary Vitamin E Does Not Inhibit the Promotion of Liver Carcinogenesis by Polychlorinated Biphenyls in Rats, Journal of Nutrition, 135(2), 283-6, 2005. free full-text article

Hennig, B., M. Toborek, P. Ramadass, G. Ludewig and L.W. Robertson. Poly-chlorinated biphenyls, oxidative stress and diet. Reviews in Food and Nutrition Toxicity, vol. 3, pages 93-128.

Lu, Zijing, Eun Y. Lee, Larry W. Robertson, Howard P. Glauert, and Brett T. Spear. Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-B. Toxicological Sciences 81, 35-42 (2004). free article

Kania-Korwel, I., S. Parkin, L.W. Robertson, H.-J. Lehmler. Synthesis of polychlorinated biphenyls and their metabolites with a modified Suzuki-coupling. Chemosphere 56, 735-744 (2004).

Espandiari, P., H.P. Glauert, H.-J. Lehmler, E.Y. Lee, C. Srinivasan and L.W. Robertson. Initiating Activity of 4-Chlorobiphenyl Metabolites in the Resistant Hepatocyte Model. Toxicological Sciences 79, 41-46 (2004). free article

Gauger, K.J., Y. Kato, K. Haraguchi, H.-J. Lehmler, L.W. Robertson, R. Bansal and R.T. Zoeller. Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-Like Effects in the Fetal Rat Brain but do not Bind to Thyroid Hormone Receptors. Environ. Health Perspect. 112, 516-523 (2004). free article

Machala M., L. Bláha, H.-J. Lehmler, M. Plísková, Z. Májková, P. Kapplová, I. Sovadinová, J. Vondrácek, T. Malmberg and L.W. Robertson. Toxicity of Hydroxylated and Quinoid PCB Metabolites: Inhibition of Gap Junctional Intercellular Communication and Activation of Aryl Hydrocarbon and Estrogen Receptors in Hepatic and Mammary Cells. Chem. Res. Toxicol. 17, 340-347 (2004). abstract

Kania-Korwel I., L.W. Robertson, H.-J. Lehmler and S. Parkin. 2,4,6-Trichloro-iodobenzene. Acta Cryst. E59 (Part 11), o1770-o1771 (2003 Nov.). abstract

Ramadass P., P. Meerarani, M. Toborek, L.W. Robertson and B. Hennig. Dietary Flavonoids Modulate PCB-induced Oxidative Stress, CYP1A1 Induction, and AhR-DNA Binding Activity in Vascular Endothelial Cells. Toxicological Sciences 76, 212-219 (2003). abstract

Kania-Korwel I., H.-J. Lehmler, L.W. Robertson and S. Parkin. 2,4,5-trichloro-1-iodobenzene. Acta Crystallographica, Section E (Structure Reports Online). 59(Part 7):o1048-o1049, 2003 Jul. abstract

Choi W., Eum S.Y., Lee Y.W., Hennig B., Robertson L.W., Toborek M. PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol. Sci., 75, 47-56 (2003). free article

Lu Z, J.C. Tharappel, E.Y. Lee, L.W. Robertson, B.T. Spear and H.P. Glauert, Effect of a single dose of polychlorinated biphenyls (PCBs) on hepatic cell proliferation and the DNA binding activity of NF-kB and AP-1 in rats. Molec. Carcinogenesis, 37(4), 171-180 (2003). abstract

Lee Y.W., H.J. Park, K.W. Son, B. Hennig, L.W. Robertson and M. Toborek. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol. Appl. Pharmacol., 189(1),1-10 (2003). abstract

Nilufer M. Tampal, Larry W. Robertson, Cidambi Srinivasan and Gabriele Ludewig. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicol. Appl. Pharmacol. 187, 168-177 (2003). abstract

Tampal N., S. Myers and L. W. Robertson. Binding of Polychlorinated Biphenyls / metabolites to Hemoglobin. Toxicology Letters, 142, 53-60 (2003). abstract

Arif J. M., H.-J. Lehmler, L. W. Robertson and R. C. Gupta. Interaction of benzoquinone- and hydroquinone-derivatives of lower chlorinated biphenyls with DNA and nucleotides in vitro. Chemico-Biological Interactions 142, 307-316 (2003). abstract

Espandiari P., H. P. Glauert, H.-J. Lehmler, E. Y. Lee, C. Srinivasan and L. W. Robertson. Polychlorinated biphenyls as initiators in liver carcinogenesis: resistant hepatocyte model. Toxicol. Appl. Pharmacol. 186, 55-62 (2003). abstract

Kania-Korwel I., H.-J. Lehmler, L.W. Robertson and S. Parkin, 2,4,5-Trichloro-1-iodobenzene. Acta Cryst. E59, o1048 - o1049 (2003).

Tampal N., H.-J. Lehmler, P. Espandiari, T. Malmberg and L. W. Robertson. Glucuronidation of hydroxylated Polychlorinated Biphenyls (PCBs). Chem. Res. Toxicol. 15, 1259-1266 (2002). abstract

Hennig B, P. Meerarani, R. Slim, M. Toborek, A. Daugherty, A. Silverstone and L. W. Robertson. Proinflammatory properties of coplanar PCBs: In vitro and in vivo evidence. Toxicol. Appl. Pharmacol. 181, 174-183 (2002). abstract

Hennig B., B. D. Hammock, R. Slim, M. Toborek, V. Saraswathi, and L. W. Robertson. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int. J. Hyg. Environ. Health 205, 95-102 (2002). abstract

Lehmler H.-J., L. W. Robertson and S. Parkin. 2-(3,5-Dichlorophenyl)-1,4-benzoquinone. Acta Crystallographica Section E, E58, o366-0367 (2002).

Srinivasan, A., L.W. Robertson and G. Ludewig. Sulfhydryl binding and topoisomerase inhibition by PCB Metabolites. Chem. Res. Toxicol. 15, 497-505 (2002). abstract

Fadhel Z., Z. Lu, L.W. Robertson and H.P. Glauert. Effect of 3,3',4,4'-tetrachloro-biphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl on the induction of hepatic lipid peroxidation and cytochrome P-450 associated enzyme activities in rats. Toxicology 175, 15-25 (2002). abstract

Tharappel J.C., E.Y. Lee, L.W. Robertson, B.T. Spear and H.P. Glauert. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by Polychlorinated Biphenyls. Toxicol. Appl. Pharmacol. 179, 172-184 (2002). abstract

Lehmler H.-J., L. W. Robertson, S. Parkin and C. P. Brock. Z'=4 structure without obvious pseudosymmetry: implications for the formation of solid-state compounds. Acta Crystallographica Section B B58, 140-147 (2002). abstract

Pereg D., L. W. Robertson and R. C. Gupta. DNA adduction by polychlorinated biphenyls: adducts derived from hepatic microsomal activation and from synthetic metabolites. Chemico-Biological Interactions 139, 129-144 (2002). abstract

Lehmler H.-J., S. Parkin and Larry W. Robertson. The three-dimensional structure of 3,3',5'-trichloro-4-methoxybiphenyl, a "coplanar" polychlorinated biphenyl (PCB) derivative. Chemosphere 46, 485-488 (2002). abstract

Lehmler H.-J., L. W. Robertson and S. Parkin. 4-Chloro-3',4'-dihydroxybiphenyl. Acta Crystallographica Section E, 57, o590-o591 (2001).

Slim R., B.D. Hammock, M. Toborek, L.W. Robertson, J.W. Newman, C.H.P. Morisseau, B.A. Watkins, V. Saraswathi and B. Hennig. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol. Appl. Pharmacol. 171, 184-193 (2001). abstract

Lehmler H.-J., S. Parkin and L. W. Robertson. 2,3,4-Trichlorobiphenyl. Acta Crystallographica Section E, 57, o111-o112 (2001).

Lehmler H.-J. and L. W. Robertson. Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling. Chemosphere 45, 1119-1127 (2001). abstract

Pereg D., N. Tampal, P. Espandiari and L. W. Robertson. Distribution and macromolecular binding of benzo[a]pyrene and two Polychlorinated Biphenyl congeners in female mice. Chem.-Biol. Interact. 137, 243-258 (2001). abstract

Oakley G. G., A. L. Roe, R. A. Blouin, T. P. Twaroski, T. C. Ganguly, M. Vore, H.-J. Lehmler and L. W. Robertson. 2,4,4'-Trichlorobiphenyl increases STAT5 Transcriptional Activity. Molecular Carcinogenesis 30, 199-208 (2001). abstract

Twaroski T. P., M. L. O'Brien, N. Larmonier, H. P. Glauert and L. W. Robertson. Polychlorinated Biphenyl-Induced Effects on Metabolic Enzymes, AP-1 Binding, Vitamin E and Oxidative Stress in the Rat Liver. Toxicology and Applied Pharmacology 171, 85-93 (2001). abstract

Srinivasan A., H.-J. Lehmler, L. W. Robertson and G. Ludewig. Production of DNA strand breaks in vitro and Reactive Oxygen Species in vitro and in HL-60 cells by PCB Metabolites. Toxicological Sciences 60, 92-102 (2001). abstract

Twaroski T. P, M. L. O'Brien and L. W. Robertson. Effects of Selected Polychlorinated Biphenyl (PCB) Congeners on Hepatic Glutathione, Glutathione-Related Enzymes and Selenium Status: Implications for Oxidative Stress. Biochemical Pharmacology 62, 273-281 (2001). abstract

Lehmler H.- J. and L. W. Robertson. Synthesis of Polychlorinated Biphenyls (PCBs) using the Suzuki-Coupling. Chemosphere 45, 137-143 (2001). abstract

Robertson L. W. and R. C. Gupta, Chapter 2: Metabolism of polychlorinated biphenyls (PCBs) generates electrophiles and reactive oxygen species that damage DNA, In: (Eds, Gary M. Williams and Okezie I. Aruoma) Molecular Drug Metabolism and Toxicology, OICA International (UK) Limited, London, pages 16-32 (2000).

Slim R., M. Toborek, L.W. Robertson, H.J. Lehmler and B. Hennig. Cellular glutathione status modulates Polychlorinated Biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol. Appl. Pharmacol. 166, 36-42 (2000). abstract

McLean M.R., T.P. Twaroski and L.W. Robertson. Redox Cycling of 2-(x'-Mono, -Di, -trichlorophenyl)-1,4-benzoquinones, Oxidation Products of Polychlorinated Biphenyls. Arch. Biochem. Biophys. 376, 449-455 (2000). abstract

Slim R., M. Toborek, L.W. Robertson and B. Hennig. Antioxidant Protection against PCB-Mediated Endothelial Cell Activation. Toxicological Sciences 52, 232-239 (1999). abstract

Espandiari P., H.P. Glauert, E.Y. Lee and L.W. Robertson. Promoting activity of the herbicide dicamba (2-methoxy-3,6-dichlorobenzoic acid) in two-stage hepatocarcinogenesis. International Journal of Oncology 14, 79-84 (1999). abstract

Hennig B., R. Slim, M. Toborek and L.W. Robertson. Linoleic acid amplifies polychlorinated biphenyl-mediated dysfunction of endothelial cells. J. Biochem. Mol. Toxicol. 13, 83-91 (1999). abstract

Espandiari P., G. Ludewig, H.P. Glauert and L.W. Robertson. Activation of hepatic NF- B by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats. J. Biochem. Molec. Toxicol. 12, 339-344 (1998). abstract

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